MAP Kinase p38, beta (Mitogen-activated Protein Kinase p38 beta, MAP Kinase p38 beta, p38beta, P38beta2, p38b, Mitogen-activated Protein Kinase 11, MAP Kinase 11, MAPK 11, MAPK11, PRKM11, p38-2, Stress-activated Protein Kinase 2b, SAPK2b, SAPK2)

P38 beta is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by changes in osmolarity of the extracellular environment, proinflammatory cytokines and cellular stress. This protein preferentially phosphorylates transcription factor ATF2. It is activated by phosphorylation on threonine and tyrosine by MKK6, and inhibited by pyridinyl-imidazole related compounds. Highest levels of expression are found in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000 \nWestern Blot: 1:100-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M2352-09M

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

P Type

Pab

Purity

Purified by ammonium sulfate precipitation.

Isotype

IgG

References

1.Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 2.Dunham, I., et al., Nature 402(6761):489-495 (1999). 3.Enslen, H., et al., J. Biol. Chem. 273(3):1741-1748 (1998). 4.Kumar, S., et al., Biochem. Biophys. Res. Commun. 235(3):533-538 (1997). 5.Goedert, M., et al., EMBO J. 16(12):3563-3571 (1997).

Additional Info

Recognizes human p38 beta.

Alternative Names

EC=2.7.11.24