Home  >  Products  >  PERP (p53 Apoptosis Effector Related to PMP-22, Keratinocyte-associated Protein 1, KCP1, KCP-1, KRTCAP1, P53-induced Protein PIGPC1, PIGPC1, Transmembrane Protein THW, THW)
PERP (p53 Apoptosis Effector Related to PMP-22, Keratinocyte-associated Protein 1, KCP1, KCP-1, KRTCAP1, P53-induced Protein PIGPC1, PIGPC1, Transmembrane Protein THW, THW)

PERP (p53 Apoptosis Effector Related to PMP-22, Keratinocyte-associated Protein 1, KCP1, KCP-1, KRTCAP1, P53-induced Protein PIGPC1, PIGPC1, Transmembrane Protein THW, THW)

Cat no: P3353-01M

Supplier: United States Biological
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The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 1-3ug/ml, observed in human liver lysates on ~20kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P3353-01M
Reactivities: Human, Mouse, Rat, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD. Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005 Mar 25;120(6):843-56.
Additional info: Recognizes human PERP. Species sequence homology: Canine, mouse and rat.

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