PTGER3 (Prostaglandin E2 Receptor EP3 Subtype, PGE Receptor EP3 Subtype, PGE2 Receptor EP3 Subtype, PGE2-R, Prostanoid EP3 Receptor)

Supplier:

United States Biological

Cat no: P9053-26M7

PTGER3 (Prostaglandin E2 Receptor EP3 Subtype, PGE Receptor EP3 Subtype, PGE2 Receptor EP3 Subtype, PGE2-R, Prostanoid EP3 Receptor)

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:2000\nWestern Blot: 1-3ug/ml, observed in human adipose, kidney, pancreas and placenta lysates on ~55kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9053-26M7

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Sarrazin P, Hackett JA, Fortier I, Gallant MA, de Brum-Fernandes A. Role of EP3 and EP4 prostaglandin receptors in reorganization of the cytoskeleton in mature human osteoclasts. J Rheumatol. 2004 Aug;31(8):1598-606.

Additional Info

Recognizes human PTGER3.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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Reactivities

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