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Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B)

Cat no: G2034-45D

Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B)

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactiviated crosslinkers of DNA to histones.\n\nPurity: > 95% by HPLC\n\nSolubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.\n\nRelated to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, O-Deacetyl-ravidomycin

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SPECIFICATIONS

Catalog Number

G2034-45D

Size

500ug

Purity

> 95% by HPLC

References

1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated \ngilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921. \n2. Photoactivated gilvocarcin V induces DNA-protein crosslinking in genes for human ribosomal RNA and \ndihydrofolate reductase. Matsumoto A. et al. Photochem. Photobiol. 1994, 60, 225. \n3. Activation of antitumor agent gilvocarcins by visible light. Elespuru R.K. & Gonda S.K. Science 1984, \n223, 69. \n4. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz D.M. et al. J. Antibiot. \n1981, 34, 1544-1555.

Alternative Names

Anandimycin A, Toromycin B, Antibiotic 1072B

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