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JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like...
The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in...
The transcriptional enhancer factor (TEF)/TEAD family of proteins includes TEF-1, TEF-3, TEF-4 and TEF-5, all of which share a highly conserved 68 amino acid...
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes...
Members of the Ikaros family contain zinc-finger domains that are involved in DNA-binding and in the formation of homodimers and heterodimers between Ikaros...
OSR (odd-skipped related) proteins belong to the odd C2H2-type zinc-finger protein family and are involved in embryonic development and bone formation. OSR2...
Members of the NK-2 family of homeodomain proteins, which include Nkx-2.2, Nkx-2.5, Nkx-2.6 and Nkx-2.8, are key regulators of growth and development in...
ALY (also designated THO complex subunit 4, THOC4, REF1, Refbp1 and BEF) is the mammalian homolog of the yeast mRNA export factor Yralp. A transcriptional...
Raly, also known as hnRNP associated with lethal yellow homolog, autoantigen p542 or heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNPCL2), is a 306...
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind...
The Insulin-like growth factor binding proteins, or IGFBPs, are a family of seven proteins that have co-evolved with the IGFs. IGFBPs serve as shuttle...
Classically, adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a...
Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions, including acting as a...
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal...
The cloning and characterization of Tie-1 (also designated Tie), a novel human endothelial cell surface receptor tyrosine kinase, has been reported. The...
Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with...
CD1E, also known as R2 or CD1A, is a 322 amino acid single-pass type I membrane protein that localizes to the lumen of the endoplasmic reticulum, as well as...
The Endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and...
The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble...
The majority of the large number of receptor tyrosine kinases that have been identified can be categorized into distinct families based on the structure of...
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