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Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene...
PHKG1 (Phosphorylase kinase subunit gamma 1), is a subunit of phosphorylase kinase (PHK) that belongs to the Ser/Thr protein kinase family. PHK is a...
PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain...
Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl...
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase...
MASTL (microtubule associated serine/threonine kinase-like), also known as GW, THC2 or serine/threonine-protein kinase greatwall, is an 879 amino acid...
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular...
The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs). Four mammalian IRAKs have...
The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine...
Ephrin receptors bind members of the ephrin ligand family. They are divided into 2 groups based on the similarity of their extracellular domain sequences and...
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors...
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors...
DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate...
The majority of the large number of receptor tyrosine kinases that have been identified can be categorized into distinct families based on the structure of...
For instance, a mutant of c-Src, in which Y527 is replaced by phenylalanine, is transforming and displays 5 to 10-fold elevated kinase activity compared to...
Human cells contain two related protein kinases, BUB1 and BUBR1, that appear to have evolved from a single ancestral BUB1 gene. Both kinases are concentrated...
The cytokine TNF (tumor necrosis factor) signals through the TNF-R1 receptor to activate various cellular pathways, including apoptosis and NFkB activation....
Bag-3 (Bcl-2-associated athanogene 3), also known as BIS or CAIR-1, is a 575 amino acid protein that contains one C-terminal Bag domain and two N-terminal WW...
M-RIP (myosin phosphatase Rho interacting protein), also known as MPRIP, p116Rip, RIP3 or RHOIP3, is a 1,025 amino acid cytoplasmic and cytoskeletal protein...
The KIR2 subunit family includes 2.1, 2.2, 2.3 and 2.4. Unlike G-protein coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP...
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