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Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor...
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved...
Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased...
AMPKbeta1 is a member of the SNF1 kinase family. It is a heterotrimeric protein comprising of an alpha (catalytic), beta (non-catalytic) and gamma...
The Ras-related Rho subfamily of GTP-binding proteins (p21s), which includes Rho, Rac and Cdc42Hs, is implicated in different aspects of cytoskeletal...
Follistatin is a high affinity binding protein of Activin originally isolated for its role in regulating the release of follicle-stimulating hormone (FSH)....
Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD2 (for mitotic...
Cleavage of the serine proteinase plasminogen to form plasmin is the central event in the dissolution of blood clots by the fibrinolytic system. Within the...
Tollip (toll-interacting protein) serves as a suppressor of innate immunity signaling and links the serine/threonine kinase IRAK to the IL-1 receptor complex...
RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX3 is...
Glypican-5 is also known as GPC5 and is a 572 amino acid protein. Glypican-5 is primarily expressed in adult brain tissue (where it is localized to neurons),...
Members of the FAM3 family were identified based on structural, but not sequence, homology to short chain cytokines including IL-2, IL-4 and GM-CSF. FAM3...
Microcephalin (MCPH1, BRCT-repeat inhibitor of TERT expression 1, BRIT1) modulates brain size and has been proliferating under strong positive selection for...
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated...
Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e., the formation of Fibrin) and determination of plasma...
Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of...
p53 is a transcription factor that mediates cell cycle arrest and apoptosis by binding to DNA and activating the transcription of specific genes. p53 is also...
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S,...
ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass...
Angiogenesis is mainly regulated by the balance of several different pro-angiogenic stimulators, such as vascular endothelial growth factor (VEGF) and a...
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