Genomics
Genomics, or the study of genetics across populations, has already led to amazing breakthroughs in disease prevention and treatment. For example, researchers studying people with Down syndrome, caused by a genetic mutation, recently discovered one molecular pathway leading to learning disabilities, and were able to reverse these in a mouse model. Cancer genomics, or the classification...
...of tumors by genetic sequencing, as opposed to location within the body, may lead to improved outcomes. Genomics also covers the study of how drugs and environmental toxins affect DNA, as well as the protein expression of DNA.
Now that the cost for sequencing DNA has been reduced to several thousand dollars per person, “precision medicine,” or “personalized medicine,” which uses knowledge of an individual’s unique genome to treat, or pre-treat illnesses, is expected to grow exponentially, although objections to personalized medicine remain due to the fact that it may lead to expensive, unnecessary and possibly harmful treatments.
An essential step in genomics research is separating DNA molecules from bodily fluids or tissues. This preparation requires centrifuging the sample, straining DNA out with micro filters, or separating it by gel electrophoresis. To run large-scale genomic assays, the DNA is treated with reverse transcriptase to create complementary DNA (cDNA), tagged with fluorescent or dye molecules, hybridized to a validated probe array on the surface of a microarray slide, and then scanned and analyzed.
Once an organism’s DNA is sampled and stored, the data are compared with validated genomic libraries or databases to identify the differences between that individual and the whole population.
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