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Drug Discovery

Drug Discovery
Looking for reliable and cost effective Drug Discovery products for your research?

The drug discovery and development process has traditionally taken 12 to 15 years to identify a potential target and molecule in the lab; synthesize and screen the molecule; test the molecule in vitro and in humans; perform clinical trials; obtain regulatory approval (Pharmacopeia, GLP and/or ISO); develop and scale-up manufacturing processes; and begin commercial production and shipping.

Because of the extended time to market and expense of developing new drugs, the pharmaceutical business is focusing on more disruptive discoveries, such as curing an incurable disease or preventing a disease, rather than just developing new drugs that produce only slight improvements. New paradigms in drug discovery are evolving to reduce development time and expense by networking multi-functional teams which are patient-focused.

Laboratory instruments for drug discovery include protein interaction array systems; gamma counters; HPLC systems; microplate luminometers and fluorometers; mass spectrometers; microarray scanners; hybridization reaction stations; and modular plant imaging systems.

Equipment, consumables and services for drug discovery labs include transfection reagents; cDNA and RNA synthesis kits; assay and ELISA kits; melting point apparatuses; microplate washers; cryogenic freezers; cryogenic tubes; ergonomic and multichannel pipettes and pipette tip racks and refills; pluripotent stem cells; reaction plates and modules; tumor tissue with matched blood samples; custom protein production in E. coli; injection services; DNA sequencing services; tissue homogenizers; and biobanking software.

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HPLC-Based Quality Peptide Mapping Assays Service
HPLC-Based Quality Peptide Mapping Assays Service
MtoZ Biolabs

HPLC peptide mapping analysis integrates the separation capabilities of high-performance liquid chromatography (HPLC) with the qualitative and quantitative...

Edman Degradation for N-Terminal Sequence Analysis Service
Edman Degradation for N-Terminal Sequence Analysis Service
MtoZ Biolabs

The N-terminal sequence is closely related to the function and stability of proteins. The analysis of the N-terminal sequence of proteins can determine the...

Oligosaccharide Chain Structure Analysis Service
Oligosaccharide Chain Structure Analysis Service
MtoZ Biolabs

Glycosylation has significant impacts on the efficacy, stability, and immunogenicity of biopharmaceuticals. Among these, the oligosaccharide spectrum and...

Monosaccharide Composition Analysis Service
Monosaccharide Composition Analysis Service
MtoZ Biolabs

Monosaccharides are the simplest form of sugar molecules and cannot be further hydrolyzed into smaller units. Monosaccharide composition profiling refers to...

N-Glycosylation Site Analysis Service
N-Glycosylation Site Analysis Service
MtoZ Biolabs

N-glycosylation is a common form of glycosylation modification in eukaryotes. Under the catalytic action of glycosyltransferases, oligosaccharide chains form...

Glycosylated Peptides Analysis Service
Glycosylated Peptides Analysis Service
MtoZ Biolabs

Glycosylation is a common post-translational modification (PTM) of proteins, which significantly affects the function and stability of proteins. Glycosylated...

Gene Knockout for Drug Screening and Target Identification
Gene Knockout for Drug Screening and Target Identification
MtoZ Biolabs

A key step in drug discovery is target identification-identifying "druggable" biological targets. After a target is identified, it must be validated to...

Disulfide Bond Mapping Analysis Service
Disulfide Bond Mapping Analysis Service
MtoZ Biolabs

Disulfide bonds are a crucial structural element in proteins, formed by the sulfur atoms from cysteine amino acid residues under oxidative conditions. These...

mRNA 3' poly(A) Tail Analysis Service
mRNA 3' poly(A) Tail Analysis Service
MtoZ Biolabs

In eukaryotic cells, the 3' end of mRNA is often extended with a poly(A) tail, a sequence of purine nucleotides. The poly(A) tail is a long chain of...

Differential Scanning Calorimetry (DSC) Analysis Service
Differential Scanning Calorimetry (DSC) Analysis Service
MtoZ Biolabs

Thermal stability is defined as the ability of a substance to resist irreversible chemical or physical changes at elevated temperatures, typically by...

SEC Based Molecular Size Variation Analysis Service
SEC Based Molecular Size Variation Analysis Service
MtoZ Biolabs

Molecular size variation critically influences the properties of biomacromolecules such as proteins, antibodies, and peptides, especially in the realms of...

CE-SDS Based Molecular Size Variation Analysis Service
CE-SDS Based Molecular Size Variation Analysis Service
MtoZ Biolabs

Aggregation or fragmentation of protein molecules primarily causes variations in molecular size, impacting their biological activity, stability, and their...

Colorimetric Analytical Based Protein Content Analysis Service
Colorimetric Analytical Based Protein Content Analysis Service
MtoZ Biolabs

The determination of protein content is a fundamental task in protein-related bioscience, medical research, and biopharmaceutical fields. Despite various...

Glycan Profiling Service
Glycan Profiling Service
MtoZ Biolabs

Glycosylation is an important post-translational modification of proteins. Based on the different linkage modes between the glycan and peptide chains,...

FT-IR for Protein and Peptide Analysis Service
FT-IR for Protein and Peptide Analysis Service
MtoZ Biolabs

Fourier transform infrared (FT-IR) spectroscopy is a powerful technique for obtaining the infrared spectra of absorption/emission in solids, liquids, or...

Protein Spectrometric Analysis Service
Protein Spectrometric Analysis Service
MtoZ Biolabs

MALDI-TOF analysis of peptide mixtures is capable of tolerating moderate amounts of buffers and salts, with peptide fragments predominantly producing singly...

Peptide Coverage/Peptide Spectrum Match (PSM) Analysis Service
Peptide Coverage/Peptide Spectrum Match (PSM) Analysis Service
MtoZ Biolabs

Protein sample identification generally only uses Trypsin for protein digestion, with peptide coverage identified around 60%. To obtain the complete sequence...

Sialic Acid Content Analysis Service
Sialic Acid Content Analysis Service
MtoZ Biolabs

Sialic acid, a carbohydrate prevalent throughout nature, primarily composes the glycoproteins and glycolipids of animal cell membranes and secretions, as...

Host Cell Protein (HCP) Content Detection Service
Host Cell Protein (HCP) Content Detection Service
MtoZ Biolabs

Host cell proteins (HCP) content analysis, a critical quality control measure, is essential for determining and quantifying the content of HCP in the final...

cIEF Protein Isoelectric Points Analysis Service
cIEF Protein Isoelectric Points Analysis Service
MtoZ Biolabs

The isoelectric point (pI) of a protein is closely related to its amino acid sequence and three-dimensional structure. The pI of a specific protein is fixed,...

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