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1,5-Isoquinolinediol (5-Hydroxy-1(2H)-isoquinolinone, 1,5-Dihydroxyisoquinoline)

1,5-Isoquinolinediol (5-Hydroxy-1(2H)-isoquinolinone, 1,5-Dihydroxyisoquinoline)

Cat no: 044432

Supplier: United States Biological
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PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: +4 degrees C Stable for at least 2 years after receipt when stored at +4 degrees C.
Catalogue number: 044432
Size: 5mg
Purity: >98% (NMR)
Alternative names: 5-Hydroxy-1(2H)-isoquinolinone, 1,5-Dihydroxyisoquinoline
References: Product Reference: ?Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) ?Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) ?Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006) ?1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003) ?

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