10'-Desmethoxystreptonigrin is a close analogue of streptonigrin which is produced by selected Streptomyces species. It is a moderately potent inhibitor of farnesylation of RAS P21 protein, 3-fold more active than streptonigrin. 10'-desmethoxystreptonigrin has also been reported to have potent and broad spectrum antibacterial and antitumor activity.
Purity: >95% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Catalogue number:
D3220-89
Size:
500ug
Purity:
>95% by HPLC
Alternative names:
10'-Demethoxystreptonigrin
References:
1. 10'-desmethyloxystreptonigrin, a novel analog of streptonigrin. Liu W.C. et al. J. Antibiot. 1992, 45, 454.