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14-3-3 zeta (14-3-3 Protein zeta/delta, Protein Kinase C Inhibitor Protein 1, KCIP-1, YWHAZ)

Cat no: 0014-22E

14-3-3 zeta (14-3-3 Protein zeta/delta, Protein Kinase C Inhibitor Protein 1, KCIP-1, YWHAZ)

14-3-3 z is a member of a conserved family of proteins that interact with hundreds of different proteins and thus mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 z is localized mostly on dense granules and is secreted after platelet activation. The protein is highly abundant in brain. The protein act as an activators of tyrosine and tryptophan hydroxylases. Human 14-3-3 z gene is located on chromosome 8q23.1, which is close to a probable bipolar disorder susceptibility locus 8q24.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nNIH/3T3 cells\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

0014-22E

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Yanbin. J. et al. European Psychiatry. 19:377-379 (2004).

Additional Info

Recognizes human 14-3-3 zeta. Species Crossreactivity: mouse and rat.

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