Home  >  Products  >  17-DMAG Hydrochloride (17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride) (17-DMAG Hydrochloride, NSC-707545, Alvespimycin)

17-DMAG Hydrochloride (17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride) (17-DMAG Hydrochloride, NSC-707545, Alvespimycin)

Cat no: D8072-60


Supplier: United States Biological
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Solubility: Soluble in DMSO; soluble up to about 2mg/ml in water. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: D8072-60
Size: 250mg
Form: Supplied as a purple powder.
Purity: ~99%
References: 1. Egorin, M.J., et al. "Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats." Cancer Chemother. Pharmacol. 49:7-19 (2002). 2. Tian, Z.Q., et al. "Synthesis and biological activities of novel 17-aminogeldanamycin derivatives." Bioorg. Med. Chem. 12:5317-5329 (2004). 3. Kaur, G, et al. "Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator." Clin. Cancer Res. 10:4813-4821 (2004). 4. Bull, E.E., et al. "Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin." Clin. Cancer Res. 10:8077-8084 (2004). 5. Hollingshead, M., et al. "In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative." Cancer Chemother. Pharmacol. 56:115-125 (2005).

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