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2-Hydroxyisoquinoline-1,3(2H,4H)-dione

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

Cat no: 013654

Supplier: United States Biological
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2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. It was investigated its interaction with Mg2+ and Mn2+ using different spectroscopic techniques and report that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent. Form: Brown Solid Melting Point: 197-200 degrees C Solubility: DMSO
Catalogue number: 013654
Size: 100mg
Form: Brown Solid
Alternative names: 2-Hydroxy-1,3(2H,4H)-isoquinolinedione;
References: Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),

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