21-hydroxyoligomycin A (Nemadectin omega, Antibiotic LL-F28249 omega)

21-Hydroxyoligomycin A is a rare member of the oligomycin class isolated as a co-metabolite of nemadectin, hence its original naming as nemadectin omega. Only limited literature references to this metabolite are available. However, in-house testing suggests that 21-hydroxyoligomycin has a more selective action against mammalian tumor cell lines than oligomycin A, exhibiting only weak antifungal and nematocidal activity.\n\nSolubility: \nSoluble in ethanol, methanol, DMF or DMSO.\n \nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

H9112

Size

1mg

Form

Supplied as a white lyophillized powder.

Purity

>95% by HPLC

References

1. Structure and Absolute Stereochemistry of 21-Hydroxyoligomycin A. Wagenaar M.M. et al. J. Nat. Prod. 2007, in press. \n2. Plasmid effects on secondary metabolite production by a streptomycete synthesizing an anthelmintic macrolide.Thomas D.I. et al. J. Gen. Microbiol. 1991, 137, 2331.

Alternative Names

Nemadectin omega, Antibiotic LL-F28249 omega