PolyMate is a special 2x additive for use in reactions involving any thermostable DNA Polymerase. PolyMate provides an optimised composition of reagents, leading to a dramatic improvement of reaction specificity. PolyMate is recommended for use with all Bioline thermostable DNA polymerases. By making DNA more accessible for Polymerase and oligonucleotides, PolyMate acts as a 'melting' agent for dirty and mainly difficult templates with high GC- or AT- content, and repetitive sequences, or templates with a difficult melting profile. PolyMate does not contain Mg, dNTPs, or buffer components.