TNFSF9, a type II transmembrane glycoprotein and member of the TNF superfamily, preferentially expressed by B cells, which acts as a ligand for CD137 (4-1BB ligand receptor/TNFRSF9). Interaction between 4-1BBL and its receptor acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells (Tc) and in the process of antigen presentation. Expression of 4-1BBL by a variety of carcinoma cells, suggests a role for 4-1BBL in tumor cell-T cell interactions.
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
ELISA: 0.5-2ug/ml
Western Blot: 0.1-0.2ug/ml
Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies:
Goat Anti Rabbit IgG (H&L) HRP
Sheep Anti Rabbit IgG Biotin
Goat Anti Rabbit IgG (Fc) FITC, HRP
Goat Anti Rabbit IgG (H&L) HRP
Sheep Anti Rabbit IgG FITC
Sheep Anti Rabbit IgG RPE
Sheep Anti Rabbit IgG DyLight(TM)488, DyLight(TM)549, DyLight(TM)649
Sheep Anti Rabbit IgG HRP
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 100ul dH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For long term storage the addition of 0.09% sodium azide is recommended. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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