4-1BB LIGAND, (TNFSF9, 4-1BBL, 4-1BB-L, Tumor necrosis factor ligand superfamily member 9), Recombinant Human

4-1BB Ligand (4-1BBL/TNFSF9) is preferentially expressed by B cells, and is a ligand for CD137 (4-1BB ligand receptor/TNFRSF9). Interaction between 4-1BBL and its receptor acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells and in the process of antigen presentation. Expression of 4-1BBL by a variety of carcinoma cells, suggests a role for 4-1BBL in tumor cell-T cell interactions.\n\nSource:\nPurified recombinant 4-1BBL expressed in E.coli\n\nActivity: \nDetermined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml. Please note: Results may vary with PBMC donors.\n\nApplications:\nSuitable for use in Functional Assays. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nEndotoxin: \n(same/less than)1EU/ug.\n\nStorage and Stability:\nLyophilized powder may be stored at-20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with 200ul dH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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