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5-Methylcytosine (5mC, 5-Methyl-Cytosine, 5 MethylCytidine, 5 MeCyd, 5 Me Cytidine)

5-Methylcytosine (5mC, 5-Methyl-Cytosine, 5 MethylCytidine, 5 MeCyd, 5 Me Cytidine)

Cat no: 029406

Supplier: United States Biological
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5-Methylcytosine is a modified base found in the DNA of higher eukaryotes. Methylation of DNA is known to be involved in the control of gene expression and is mediated by a class of enzymes known as DNA methyltransferases (DNMT's). Appropriate cytosine methylation is essential for normal development and maintenance of mammalian cells. Alternations in DNA methylation patterns is often associated with cancers with the turmor DNA being hypomethylated compared to DNA from normal tissues. Applications: Suitable for use in Dot Blot. Other applications not tested. Recommended Dilution: Dot Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Methylated and unmethylated BRCA1 Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 029406
Reactivities: Human
Hosts: Mouse
Size: 100ug
Form: Supplied as a liquid in PBS. No preservatives added.
P type: Mab
Isotype: IgG1,l
Purity: Purified by Protein A affinity chromatography.
References: 1. Habib, M., et al. (1999). Exp Cell Res. 249:46-53. 2.Tweedies, S., et al. (1997). Mol Cell Biol. 17(3):1469-1475. 3. Hernadez-Blazquez, F.J., et al. (2000). Gut. 47:689-693.
Additional info: Recognizes human 5-Methylcytosine. Species sequence homology: Mouse

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