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Products 6-ECDCA (6alpha-Ethyl-chenodeoxycholic acid, 6-alpha-ECDC, Obeticholic acid, INT-747)
| Catalogue number: | 044442 |
| Size: | 5mg |
| Purity: | >95% (HPLC) |
| Alternative names: | 6alpha-Ethyl-chenodeoxycholic acid, 6-alpha-ECDC, Obeticholic acid, INT-747 |
| References: | Product Reference: ?6r-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity: R. Pellicciari, et al.; J. Med. Chem. 45, 3569 (2002) ?A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis: S. Fiorucci, et al.; J. Pharmacol. Exp. Ther. 314, 584 (2005) ?Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis: S. Fiorucci, et al.; J. Pharmacol. Exp. Ther. 313, 604 (2005) ?The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo: G. Rizzo, et al.; Mol. Pharmacol. 70, 1164 (2006) ?Farnesoid X receptor ligands inhibit vascular smooth muscle cell inflammation and migration: Y.T. Li, et al.; Arterioscler. Thromb. Vasc. Biol. 27, 2606 (2007) ? |
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