Home  >  Products  >  a-Fetoprotein (AFP, Alpha-1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein precursor, FETA, HPAFP )
a-Fetoprotein (AFP, Alpha-1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein precursor, FETA, HPAFP )

a-Fetoprotein (AFP, Alpha-1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein precursor, FETA, HPAFP )

Cat no: F4100-14E

Supplier: United States Biological
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Alpha fetoprotein receptor (AFP receptor) is a 62-67kD cell surface protein that mediates the uptake of AFP by proliferating or differentiating cells. AFP is expressed during gestation, but after birth levels in healthy adults drop to trace amounts. High expression of AFP and AFP receptor in adults can be indicative of certain cancers, especially hepatocellular carcinoma. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin): Does not require protein digestion pre-treatment of paraffin sections. Does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4100-14E
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 200ug
Form: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
References: 1. Li, M. S. et al (2002) The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells. Cell Res. 12:151-156. 2. Wang, X. W. and Xu, B. (1998) Stimulation of tumor-cell growth by alpha-fetoprotein. Int. J. Cancer 9:596-599.
Additional info: Recognizes human alpha fetoprotein receptor (AFP receptor).

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