a-Fetoprotein Transcription Factor (Alpha-1-fetoprotein Transcription Factor, AFPTF, AFP, B1-binding Factor, B1F, hB1F, B1F2, hB1F-2, CYP7A Promoter-binding Factor, CPF, FTF, FTZ-F1, FTZ-F1beta, Hepatocytic Transcription Factor, Liver Receptor Homolog 1,

Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as Human B1-binding factor (HB1F), CYP7A promoter-binding factor (CPF), and liver receptor homolog 1 (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis. Ftf has been shown to regulate aromatase activities in adipose tissue, and alterations in Ftf expression and/or activity in adipose tissue could have considerable effects on local estrogen production and breast cancer development. LRH has been shown to expressly strongly in gonadal tissues, and may play an important role in the regulation of gonadal function. Three isoforms of Ftf have been identified: wild type (495 aa), CPF variant 1 (contains a 46-aa insertion in the A/B domain), and CPF variant 2 (contains a 172-aa deletion within the D/E domain). Ftf expression has been documented in Human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal Human brain, liver/spleen, embryo and uterus tissue libraries.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 10-19ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman Liver\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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