alpha-GalCer is a specific ligand for human and mouse natural killer T (NKT) cells; exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and metastatic models in the liver and lung. KRN7000 has been reported to show various immunological effects in infectious diseases, autoimmune disease and graft verse host disease in mice.
Solubility:
For In vivo assay: Use 5.6% sucrose, 0.75% L-histidine and 0.5% Tween20 with heating at 60-80C.
For In vitro assay: should be dissolved in DMSO at the concentration of 1mg/ml with heating at 60-80C . The solution of 1mg/ml in DMSO can be diluted by PBS.
Molecular Weight:
~858.32
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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