A metabolite of the chemotherapeutic drug tamoxifen. Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.
Melting Point: 115-119 degrees C
Solubility: Chloroform, Ethyl Acetate, Methanol
Method for Determining Identity:Proton NMR Spectroscopic Analysis
TLC Conditions:
SiO2; Ethyl Acetate: Hexane: Triethylamine; 3:6:1; Visualized with UV and AMCS; Single spot; Rf=0.25
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.