a1-Acid Glycoprotein (Orosomucoid)

Alpha 1 Acid Glycoprotein (AGP) is an acute phase plasma protein synthesized by the liver. The protein is believed to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, also regulates the extravasation of the cells during infection and inflammation. AGP is a major acute phase reactant, both in human and in rat. In human plasma, AGP (44kD) is found at levels of 0.5-1.4 mg/ml. Its concentration in blood plasma is elevated during acute inflammation, such as trauma, malignancies, myocardial infarction, rheumatoid arthritis, bacterial infections, after major surgery, in cases of chronic pain etc, and can be used for the diagnosis of inflammatory conditions.\n\nCellular Localization: Secreted\n\nPositive Control: E Coli-derived fusion protein.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A0550-09B

Size

50ug

Applications

WB

Hosts

Ch/Bird

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgY

References

Prowse KR & Baumann H Molecular characterization and acute phase expression of the multiple Mus caroli alpha 1-acid glycoprotein (AGP) genes. Differences in glucocorticoid stimulation and regulatory elements between the rat and mouse AGP genes. J Biol Chem 265:10201-9 (1990). <PUBMED:2354997>

Additional Info

Species Crossreactivity: Crossreacts with Human. Not yet tested in other species.