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a1-Antichymotrypsin (AACT, Alpha1-ACT, Alpha-1-antichymotrypsin, ACT, Cell Growth-inhibiting Gene 24/25 Protein, Serpin A3, SERPINA3, GIG24, GIG25)

Cat no: A2298-01U

a1-Antichymotrypsin (AACT, Alpha1-ACT, Alpha-1-antichymotrypsin, ACT, Cell Growth-inhibiting Gene 24/25 Protein, Serpin A3, SERPINA3, GIG24, GIG25)

Alpha 1 ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1- ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT. \n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nImmunohistochemistry (Formalin/Paraffin): 1:25-1:50 for 30 minutes at RT. Stains monocytes and macrophages in human tissues and does not stain any other cell type.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nTonsil\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A2298-01U

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Meis et al. Am J Clin Pathol 86: 591, 1986. 2. Nathrath et al. Acta Histochem 25: 69, 1982.

Additional Info

Recognizes human Alpha-1-antichymotrypsin. Species Crossreactivity: most mammals.

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