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a2-Macroglobulin (Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 5, A2M, CPAMD5, FWP007)

Cat no: M1150-02B

a2-Macroglobulin (Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 5, A2M, CPAMD5, FWP007)

a2-Macroglobulin (a2M), is a 720kD homotetrameric glycoprotein composed of four identical 180kD subunit. a2M shares with other a-macroglobulins, like the complement components C3 and C4 and the pregnancy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the a-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. a2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer's disease (AD) patients, a2M also has been localized to diffuse amyloid plaques, supporting an important role for a2M in AD etiopathology.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:2000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M1150-02B

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid

P Type

Mab

Purity

Purified

Isotype

IgG1,k

Additional Info

Recognizes human a2-macroglobulin.

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