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Aa1

Cat no: RTA-400

Aa1

Aa1. A Novel Blocker of Shaker-B and IA K+ Channels.
Native Aa1 was originally isolated from Androctonus australis scorpion venom. Aa1 is a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity. Native Aa1 blocks Shaker B channels expressed in Xenopus oocytes with IC50=4.5 μM. In addition the Aa1 toxin was shown to block the fast (A-type) K+ current in cerebellum granular cells (IC50 = 134 nM, or Kd = 150 nM). In both cases the block is non voltage dependent and does not affect kinetic parameters of the K+currents.
Ion Channel Modulators; K+ Channel Blockers.

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SPECIFICATIONS

Catalog Number

RTA-400

Size

5 x 10 micro g

Purity

>98%

Concentration

100 nM - 1 micro M.

Shipping Temp

Room Temperature

Molecular Weight

3868 da

SUPPLIER INFO

Alomone Labs Ltd.

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