Apoptosis Antagonizing Transcription Factor (AATF), also known as Che-1, is a ubiquitously expressed nuclear protein. Research indicates that AATF functions as a general inhibitor of the histone deacetylase HDAC1. It has been also demonstrated that AATF activates transcription factor E2F and that it is involved in the activation of anti-apoptotic pathways. AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human testis
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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