Abi-1 (L201) Peptide

The Abl interactor proteins, Abi-1 and Abi-2, are SH3-domain containing proteins that bind to the proline-rich motifs of Abl and activate the kinase function. Two splice variants of Abi-1 are widely expressed, with the highest levels found in bone marrow,spleen, brain and testis. Abi-1 and Abi-2 are thought to negatively regulate cell growth and transformation, including cellular transformation through v-Abl. ABI1, the gene encoding Abi-1, has been shown to translocate and fuse with MLL (mixed lineage leukemia) gene in some cases of acute myeloid leukemia (AML). The Abi proteins have also been identified as mediators of cell motility by regulating Actin polymerization in lamellipodia and filopodia.

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SPECIFICATIONS

Catalog Number

BS3529P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Abi-1 (L201). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q8IZP0

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3529 Abi-1 (L201) pAb.

Alternative Names

Abl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1; SSH3BP1; ABI1