AcCoA Acetyltransferase 2 (ACAT2, Acetyl Coenzyme A Acetyltransferase 2, Acetoacetyl Coenzyme A Thiolase) Recombinant, Human

Supplier:

United States Biological

Cat no: A0220-01A

AcCoA Acetyltransferase 2 (ACAT2, Acetyl Coenzyme A Acetyltransferase 2, Acetoacetyl Coenzyme A Thiolase) Recombinant, Human

Acetyl-Coenzyme A acetyltransferase 2 is an enzyme involved in lipid metabolism. Reported patients with ACAT2 deficiency have shown severe mental retardation and hypotonus. The ACAT2 gene shows complementary overlapping with the 3 prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.\n\nDescription: \nRecombinant Human ACAT-2 produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids 1-397 and having a total molecular mass of 41.3kD. Recombinant ACAT2 contains T7 tag at N-terminus and is purified by proprietary chromatographic techniques.\n\nApplications: \n

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SPECIFICATIONS

Catalog Number

A0220-01A

Size

2ug

Form

Supplied as a liquid in 10mM Tris, pH 8.0, 0.1M sodium chloride, 1mM DTT and 20% glycerol.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2. FEBS Lett 2006 May 15;580(11):2741-9 2. Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes. Acta Biochim Biophys Sin (Shanghai) 2005 Dec;37(12):797-806 3. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. J Lipid Res 2005 Nov;46(11):2423-31 4. Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipids. J Nutr Biochem 2005 Dec;16(12):714-21 5. Control of ACAT2 liver expression by HNF1. J Lipid Res 2005 Sep;46(9):1868-76 6. ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia. Arterioscler Thromb Vasc Biol 2005 Jun;25(6):1112-8

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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