ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.
Biological Activity:
Converts angiotensin I to angiotensin-(1-9).
Sequence:
Signal peptide sequence and the extracellular domain of human ACE2 (aa 1-740) are fused at the C-terminus to a FLAG(R)-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Working aliquots are stable for up to 3 months when stored at -20 degrees C.