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ACPP pAb

ACPP pAb

Cat no: BS6510


Supplier: Bioworld Technology, Inc.
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Human prostatic acid phosphatase (also known as PAcP, PAP, PPAP, ACPP) is a prostate epithelium-specific differentiation antigen. The cellular form of PAcP functions as a neutral protein-tyrosine phosphatase, and is involved in regulating prostate cell growth. Specifically, PAcP catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. PAcP is synthesized under androgen regulation. The stimulated secretion of prostatic acid phosphatase is a hallmark of androgen action on human prostate epithelial cells, implicating PAcP as a useful tool in identifying atrophy of prostatic tissue. Cellular PAcP can down-regulate prostate cancer cell growth, at least partially by dephosphorylating c-ErbB-2/neu. Therefore, decreased cellular PAcP expression in cancer cells may be involved in prostate cancer progression. PAcP is the protein product of the human ACPP gene, which maps to chromosome 3q21-q23.
Catalogue number: BS6510
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P15309
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human ACPP.
Species: ACPP pAb detects endogenous levels of ACPP protein.
Molecular weight: ~ 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 5'-NT; 5'-nucleotidase; Acid phosphatase prostate; ACP 3; ACP3; ACPP; Ecto-5'-nucleotidase; PAP; PPAP; Prostatic acid phosphatase; Prostatic acid phosphotase; Thiamine monophosphatase; TMPase;
Additional info: For research use only, not for use in diagnostic procedure.

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