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Acrosin (Acrosin precursor, ACRS, ACR-2)

Acrosin (Acrosin precursor, ACRS, ACR-2)

Cat no: A0700-02A

Supplier: United States Biological
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ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0700-02A
Reactivities: Porcine
Hosts: Mouse
Applications: Immunocytochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, containing 15mM sodium azide
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
References: This product has been used in:Moos J et al. Protein-protein interactions controlling acrosin release and solubilization during the boar sperm acrosome reaction. Biol Reprod 49:408-15 (1993). Peknicova J & Moos J Monoclonal antibodies against boar acrosomal antigens labelling undamaged acrosomes of spermatozoa in immunofluorescence test. Andrologia 22:427-35 (1990).
Additional info: Reacts with various forms of porcine acrosin (55, 53, 45 and 35kD) in the acrosome of undamaged spermatozoa. Does not crossreact with bovine, canine or human. Not yet tested in other species.

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