Acrp30, aa111-247, Recombinant, Mouse (Adipocyte Complement-related Protein of 30kD, Adiponectin, AdipoQ, apM1, Gelatin Binding Protein 28, GPB28)

Adiponectin/Acrp30 (247 amino acids) is adipocyte complement-related protein of 30kD and exclusively expressed in differentiated adipocytes. Adiponectin (Acrp30) is a member of the complement factor C1q family and consists of signal sequence, Non-homologous sequence, collagen domain and globular domain (gAcrp30). Adiponectin (Acrp30) expression is reduced in a variety of obese and insulin-resistant states in human, monkeys and mice. Injection of Acrp30 (247aa) or gAcrp30 (globular domain) lowers serum glucose and free fatty acid level in mice.\nThe globular domain of adiponectin/acrp30 (amino acid residues, 111-247, gAcrp30) was overexpressed in E. coli and purified by using conventional chromatography techniques.\n\nMolecular Weight: \n16kD (138 amino acids)\n\nSequence:\nMAYMYRSAFS/ VGLETRVTVP/ NVPIRFTKIF/ YNQQNHYDGS/ TGKFYCNIPG/ LYYFSYHITV/\nYMKDVKVSLF/ KKDKAVLFTY/ DQYQEKNVDQ/ ASGSVLLHLE/ VGDQVWLQVY/ GDGDHNGLYA/\nDNVNDSTFTG/ FLLYHDTN\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A0725-09

Size

500ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 50mM sodium chloride, 5mM DTT and 10% glycerol.

Purity

(same/more than) 95% by SDS PAGE; Purified by conventional chromatography techniques

References

1. Fruebis, J., et al., PNAS 98(4): 2005-2010 (2001). 2. Das, K., et al., Biochem. Biophys. Res. Commun. 280(4): 1120-1129 (2001). 3. Yamauchi, T., et al., Nature Medicine 7(8): 941-946 (2001). 4. Berg, A.H., et al., Nature Medicine 7(8): 947-952 (2001). 5. Yamauchi, T., et al., Nature Medicine 8(11): 1288-1295 (2002).