Home  >  Products  >  Actinin, alpha 1 (Alpha Actinin 1, ACTN1, Alpha Actinin Cytoskeletal Isoform, F-actin Cross-linking Protein, FLJ40884, FLJ54432, Non-muscle alpha Actinin 1)
Actinin, alpha 1 (Alpha Actinin 1, ACTN1, Alpha Actinin Cytoskeletal Isoform, F-actin Cross-linking Protein, FLJ40884, FLJ54432, Non-muscle alpha Actinin 1)

Actinin, alpha 1 (Alpha Actinin 1, ACTN1, Alpha Actinin Cytoskeletal Isoform, F-actin Cross-linking Protein, FLJ40884, FLJ54432, Non-muscle alpha Actinin 1)

Cat no: A0761-01B

Supplier: United States Biological
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Alpha-actinin is a ubiquitously expressed protein found in numerous actin structures. It consists of an N-terminal actin binding domain, a central rod domain, and a C-terminal domain and functions as a homodimer to cross- link actin filaments. The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins (1).Alpha-actinins are a multigene family of four actin- binding proteins related to dystrophin. Alpha-actinin-1 and -4 (ACTN1, ACTN4) are non-muscle isoforms version of ACTN. These isoform are commonly expressed in filopodia, lamellipodia, stress fibers, sites of adhesion and intercellular contacts (2). Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:40 Western Blot: 1:500-1:1000 Immunoprecipitation: 1:40 Immunocytochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: A0761-01B
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Ylanne J, et al. Structure 9(7):597-604, 2001 2. Otey, CA and Carpen O. Cell Motil. Cytoskeleton 58:104- 111, (2004).
Additional info: Recognizes human Alpha-Actinin 1.

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