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Actinin-(alpha)3 (E25) pAb

Actinin-(alpha)3 (E25) pAb

Cat no: BS2205

Supplier: Bioworld Technology, Inc.
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The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and (alpha)-actinins. There are four tissue-specific (alpha)-actinins, namely (alpha)-actinin-1, (alpha)-actinin-2, (alpha)-actinin-3 and (alpha)-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each (alpha)-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding (alpha)-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
Catalogue number: BS2205
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: Q08043
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the N-terminus of Human Actinin-(alpha)3.
Species: Actinin-(alpha)3 (E25) pAb detects endogenous levels of actinin-(alpha)3 protein, this antibody does not cross-react with other (alpha)-actinin isoforms.
Molecular weight: ~ 103 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; ACTN3; (alpha)-Actinin3; Actinin (alpha)3; Actinin(alpha)3; (alpha)Actinin-3; Actinin-(alpha)3; (alpha)-actinin-3
Additional info: For research use only, not for use in diagnostic procedure.

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