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Activating Transcription Factor 3 (ATF3, ATF-3, Cyclic AMP-dependent Transcription Factor ATF-3, cAMP-dependent Transcription Factor ATF-3)

Activating Transcription Factor 3 (ATF3, ATF-3, Cyclic AMP-dependent Transcription Factor ATF-3, cAMP-dependent Transcription Factor ATF-3)

Cat no: A0855-58E

Supplier: United States Biological
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Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0855-58E
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG3,k
Purity: Purified by Protein A affinity chromatography.
References: 1. Steroids and extracellular signal-regulated kinase 1/2 activity suppress activating transcription factor 3 expression in patients with severe asthma. Roussel L, Robins S, Schachter A, Berube J, Hamid Q, Rousseau S.J Allergy Clin Immunol. 2011 Apr 22. [Epub ahead of print]. 2.Energy restriction-mimetic agents induce apoptosis in prostate cancer cells, in part, through epigenetic activation of KLF6 tumor suppressor gene expression. Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS.J Biol Chem. 2011 Feb 3. [Epub ahead of print]
Additional info: Recognizes human Activating Transcription Factor 3.

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