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Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2)

Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2)

Cat no: A0855-75H

Supplier: United States Biological
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Activation-induced cytidine deaminase (AID) is an RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. AID deficiency causes the autosomal recessive form of the Hyper-IgM syndrome. Expression of AID is restricted to stimulated B lymphocytes. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000-1:2,000 Western Blot: 1:1000-1:2,000 Optimal dilutions to be determined by the researcher. Hybridoma: Mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human AID protein. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0855-75H
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Ai K , et al., (2007) Proc Natl Acad Sci U S A 104(5):1616-1620 2. Mani L, et al., (2007) Mol Cell Biol 27(1):20-30 3. Okazaki I, et al., (2002) Nature 416:340-345 4. Revy P, et al., (2000) cell 102:565-575
Additional info: Recognizes human Activation-induced Cytidine Deaminase (AICDA).

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