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Activin A (Insect-derived), Recombinant Human/Murine/Rat

Cat no: 143269

Activin A (Insect-derived), Recombinant Human/Murine/Rat

Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively.The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin.Human/Murine/Rat Activin A is a 26.0kD disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.\nManufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.\n\nBiological Activity:\nThe ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ~2ng/ml, corresponding to a specific activity of ~5x10e5 units/mg.\n\nAA Sequence:\nGLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS\n\nCrossreactivity:\nChicken, Canine, Frog, Mouse, Human, Mouse\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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SPECIFICATIONS

Catalog Number

143269

Size

2ug

Form

Supplied as a lyophilized powder.

Purity

(same/more than)95% by SDS-PAGE gel and HPLC analyses.

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