Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, follistatin. Human Activin A is a 26kD disulfide-linked homodimer of two betaA chains, each containing 116aa.
Source:
Recombinant protein corresponding to human Activin A, expressed in E.coli.
Biological Activity:
Determined by its ability to inhibit the proliferation of murine MPC-11 cells. The ED50 was found to be 2ng/ml.
Specific Activity:
5x10e5units/mg
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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