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Activin B

Cat no: A0855-89B

Activin B

Activin B is a TGF-b family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-b family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 26.0kD disulfide-linked homodimer consisting of two bB chains, each containing 115 amino acid residues. \n\nApplications: \nSuitable for use in Neutralization, ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.5-1.0ug/ml. The detection limit is ~0.1ng/well.\nWestern Blot: 1-2ug/ml. The detection limit is ~0.5ng/lane and 1ug/lane under non-reducing and reducing conditions.\nNeutralization: ~5-20ug/ml to neutralize 7.5ng/ml of human Activin AB on K562 cells.\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nMouse myeloma with B cells obtained from a mouse\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A0855-89B

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 5% trehalose.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human Activin B.

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