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ACVRL1 (F231) pAb

ACVRL1 (F231) pAb

Cat no: BS2555

Supplier: Bioworld Technology, Inc.
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Mutations in two genes, Endoglin (also designated CD105) and ACVRL1 (activin receptorlike kinase 1, also designated TGF(beta) superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGF(beta) receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGF(beta) superfamily via association with the respective ligand binding receptors for TGF(beta)1, TGF(beta)3, Activin-A, BMP-2 and BMP-7. ALK-1 preferentially binds TGF(beta)1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.
Catalogue number: BS2555
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P37023
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 200-250 of Human ACVRL1.
Species: ACVRL1 (F231) pAb detects endogenous levels of ACVRL1 protein.
Molecular weight: ~ 56 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; ACVRLK1; ALK1
Additional info: For research use only, not for use in diagnostic procedure.

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