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ACVRL1 (F231) Peptide

ACVRL1 (F231) Peptide

Cat no: BS2555P


Supplier: Bioworld Technology, Inc.
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Mutations in two genes, Endoglin (also designated CD105) and ACVRL1 (activin receptorlike kinase 1, also designated TGFbeta superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFbeta receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFbeta superfamily via association with the respective ligand binding receptors for TGFbeta1, TGFbeta3, Activin-A, BMP-2 and BMP-7. ALK-1 preferentially binds TGFbeta1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.
Catalogue number: BS2555P
Applications: Block/Neutralize/Inhibit
Swiss prot: P37023
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide ACVRL1 (F231). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; ACVRLK1; ALK1
Additional info: This peptide can be used with studies using BS2555 ACVRL1 (F231) pAb.

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