ACVRL1 (F231) Peptide

Mutations in two genes, Endoglin (also designated CD105) and ACVRL1 (activin receptorlike kinase 1, also designated TGFbeta superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFbeta receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFbeta superfamily via association with the respective ligand binding receptors for TGFbeta1, TGFbeta3, Activin-A, BMP-2 and BMP-7. ALK-1 preferentially binds TGFbeta1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS2555P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide ACVRL1 (F231). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P37023

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2555 ACVRL1 (F231) pAb.

Alternative Names

Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; ACVRLK1; ALK1