Human ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain)
family of metalloproteases. Members of this family are membrane-anchored proteins
structurally related to snake venom disintegrins. They have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, such as fertilization,
muscle development, and neurogenesis. ADAM22 is highly expressed in the brain and may
function as an integrin ligand in the brain. The amino acid sequence of human ADAM22 is
100%, 96% and 92% identical to that of chimpanzee, dog and mouse.
Applications:
Suitable for use in ELISA, Western Blot, and Immunoprecipitation. Other applications not tested.
Recommended Dilution:
ELISA: 0.5-1.0ug/ml
Western Blot: 1-2ug/ml
Immunoprecipitation: 25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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