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ADAM 8 (ADAM8, a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)

ADAM 8 (ADAM8, a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)

Cat no: A0858-98D

Supplier: United States Biological
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Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker. Cellular Localization: Cell Membrane Applications: Suitable for use in RIA, Immunofluorescence, Flow Cytometry, Direct ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1.0-3.0ug/ml. ~ 90kD band seen in Human Brain lysate. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0858-98D
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CD156a antigen, Human Leukocyte Differentiation Antigen, Macrophage Cysteine Rich Glycoprotein
References: Yoshiyama K et al. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. Genomics 41:56-62 (1997).
Additional info: Species Crossreactivity: Crossreacts with Human.

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