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ADAM 8 (ADAM8, a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)

Cat no: A0858-98D

ADAM 8 (ADAM8, a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)

Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.\n\nCellular Localization: Cell Membrane\n\nApplications: \nSuitable for use in RIA, Immunofluorescence, Flow Cytometry, Direct ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1.0-3.0ug/ml. ~ 90kD band seen in Human Brain lysate.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\n\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A0858-98D

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Yoshiyama K et al. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. Genomics 41:56-62 (1997). <PUBMED:9126482>

Additional Info

Species Crossreactivity: Crossreacts with Human.

Alternative Names

CD156a antigen, Human Leukocyte Differentiation Antigen, Macrophage Cysteine Rich Glycoprotein

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