Home  >  Products  >  ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)
ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)

ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)

Cat no: A0859-10P

Supplier: United States Biological
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Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala--Val-77' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 2ug/ml Western Blot: 1:500-1:2000 Immunocytochemistry: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat whole cell lysate. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0859-10P
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Rosendahl MS, Ko SC, Long DL, et al. Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. J Biol Chem 1997;272:24588-93. 2. Pan D, Rubin GM. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997;90:271-80. 3. Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S. Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science 1999;283:91-4. 4. Howard L, Lu X, Mitchell S, Griffiths S, Glynn P. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Biochem J 1996;317:45-50. (RD1299).
Additional info: Recognizes human ADAM10.

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