Home  >  Products  >  ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)
ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)

ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)

Cat no: A0859-10Q

Supplier: United States Biological
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Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand, participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane- bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunocytochemistry: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat whole cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0859-10Q
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH7.4, 0.05% sodium azide.
P type: Pab
Purity: Purified by Ion Exchange chromatography.
References: 1. Rosendahl, MS. et al. J Biol Chem. 272, 24588 (1997). 2. Pan, D. et al. Cell 90, 271 (1997). 3. Qi, H. et al. Science 283, 91 (1999). 4. Howard, L. et al. Biochem J 317, 45 (1996).
Additional info: Recognizes human ADAM10.

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