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ADAM33 (Disintegrin and Metalloproteinase Domain-containing Protein 33, ADAM 33, C20orf153, UNQ873/PRO1891)

ADAM33 (Disintegrin and Metalloproteinase Domain-containing Protein 33, ADAM 33, C20orf153, UNQ873/PRO1891)

Cat no: A0859-42E

Supplier: United States Biological
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ADAM33 is a widely expressed member of the ADAM family of transmembrane proteins. It contains a metalloprotease-like domain, disintegrin cell adhesion domain, and cysteine rich domain. ADAM33 is involved in the maintenance of airway function, and ADAM33 polymorphisms have been associated with asthma susceptibility and bronchial hyperresponsiveness. Within the mature ectodomain, human and mouse ADAM33 share 79% aa sequence identity. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.3ug/ml ELISA: >1:64,000 Optimal dilutions to be determined by the researcher. Positive Control: Human Pancreas lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0859-42E
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Blakey J, Halapi E, Bjornsdottir US, Wheatley A, Kristinsson S, Upmanyu R, Stefansson K, Hakonarson H, Hall IP. Contribution of ADAM33 polymorphisms to the population risk of asthma. Thorax. 2005 Apr;60(4):274-6. PMID: 15790980.
Additional info: Recognizes human ADAM33.

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