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ADAMTS13 (A Disintegrin-like and Metalloprotease (reprolysin type) with Thrombospondin type 1 motif)

Cat no: A0859-61Z

ADAMTS13 (A Disintegrin-like and Metalloprotease (reprolysin type) with Thrombospondin type 1 motif)

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates at least four transcript variants encoding different isoforms.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:100-1:1,000.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A0859-61Z

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

As reported

P Type

Pab

Purity

Serum

Additional Info

Specific for human ADAM TS13 protein. Shown to react with purified recombinant ADAM-TS13. It has not been tested for reactivity with ADAM-TS13 from native sources. Species Crossreactivity: Human. Other species not tested.

Alternative Names

von Willebrand Factor-Cleaving Protease, vWF-Cleaving Protease, vWF-CP

Read more on Supplier website

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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